Tensions rise between Targaryens in first teaser for House of the Dragon S2

It's House Targaryens vs House Hightower in the second season of HBO's House of the Dragon.

HBO dropped the first teaser for the much-anticipated second season of its Game of Thrones prequel spinoff series House of the Dragon during CCXP23 in Sao Paulo Brazil. The eight episodes will cover the onset of civil war within House Targaryen, known as the Dance of Dragons.

(Spoilers for the first season below.)

As I've written previously, HBO's House of the Dragon debuted last year with a solid, promising pilot episode, and the remainder of the season lived up to that initial promise. The series is set about 200 years before the events of Game of Thrones and chronicles the beginning of the end of House Targaryen's reign. The primary source material is Fire and Blood, a fictional history of the Targaryen kings written by George R.R. Martin.

Read 9 remaining paragraphs | Comments

New algorithm finds lots of gene-editing enzymes in environmental DNA

Enlarge / The protein structure of CAS, shown with nucleic acids bound. (credit: Bang Wong, Broad Institute)

CRISPR—Clustered Regularly Interspaced Short Palindromic Repeats—is the microbial world’s answer to adaptive immunity. Bacteria don’t generate antibodies when they are invaded by a pathogen and then hold those antibodies in abeyance in case they encounter that same pathogen again, the way we do. Instead, they incorporate some of the pathogen’s DNA into their own genome and link it to an enzyme that can use it to recognize that pathogenic DNA sequence and cut it to pieces if the pathogen ever turns up again.

The enzyme that does the cutting is called Cas, for CRISPR associated. Although the CRISPR-Cas system evolved as a bacterial defense mechanism, it has been harnessed and adapted by researchers as a powerful tool for genetic manipulation in laboratory studies. It also has demonstrated agricultural uses, and the first CRISPR-based therapy was just approved in the UK to treat sickle-cell disease and transfusion-dependent beta-thalassemia.

Now, researchers have developed a new way to search genomes for CRISPR-Cas-like systems. And they’ve found that we may have a lot of additional tools to work with.

Read 12 remaining paragraphs | Comments

Porsche summons old-school cool with the 2024 911 Sport Classic

Enlarge / We never get tired of seeing the different ways Porsche finds to tweak the venerable 911. It's outdone itself with the Sport Classic, but the car comes with a price tag that means very few will experience it. (credit: Bradley Iger)

Sports cars have always been emotionally driven purchases, and perhaps no automaker understands this better than Porsche. There are more than two dozen iterations of the 911 on sale today, and while it can sometimes feel like sussing out the differences in character between one variant and another is an exercise in splitting hairs, the new Sport Classic tugs at enthusiasts' heartstrings in a way that no other modern 911 can.

Part of the Heritage Design Edition series, which includes a 911 Targa as well as two more as-yet-unnamed models, the new Sport Classic leverages the formidable capability of the latest 911 Turbo while delivering a genuinely unique driving experience and a distinct sense of style.

While its purposeful stance comes courtesy of the Turbo's widened body, elements like the bespoke carbon fiber hood, the Carrera GT-inspired carbon “double bubble” roof, and the eye-catching carbon fiber ducktail rear spoiler—the latter of which pays homage to the iconic 911 Carrera RS 2.7 of the early 1970s—help to provide the Sport Classic with a look all its own. The bodywork is also further differentiated from its Turbo sibling thanks to the deletion of the side intakes, a change that necessitated new tooling to stamp the unique panels that run from underneath the front of the doors all the way to the rear bumper. New inlets installed under the ducktail spoiler are on hand to channel air into the engine's intake system.

Read 11 remaining paragraphs | Comments

Roar of cicadas was so loud, it was picked up by fiber-optic cables

Enlarge / BUZZ BUZZ BUZZ BUZZ (credit: astrida via Getty Images)

One of the world’s most peculiar test beds stretches above Princeton, New Jersey. It’s a fiber optic cable strung between three utility poles that then runs underground before feeding into an “interrogator.” This device fires a laser through the cable and analyzes the light that bounces back. It can pick up tiny perturbations in that light caused by seismic activity or even loud sounds, like from a passing ambulance. It’s a newfangled technique known as distributed acoustic sensing, or DAS.

Because DAS can track seismicity, other scientists are increasingly using it to monitor earthquakes and volcanic activity. (A buried system is so sensitive, in fact, that it can detect people walking and driving above.) But the scientists in Princeton just stumbled upon a rather … noisier use of the technology. In the spring of 2021, Sarper Ozharar—a physicist at NEC Laboratories, which operates the Princeton test bed—noticed a strange signal in the DAS data. “We realized there were some weird things happening,” says Ozharar. “Something that shouldn’t be there. There was a distinct frequency buzzing everywhere.”

Read 11 remaining paragraphs | Comments

Severe outbreak tied to cantaloupe sickens 117 in 34 states; half hospitalized

Enlarge / Containers with cut cantaloupe in a cooler case. (credit: Getty | Ben Hasty)

The Centers for Disease Control and Prevention is warning everyone in the country to back away from pre-cut cantaloupe unless you're certain the fruit in question is not tied to a large, nationwide Salmonella outbreak that is unusually severe.

So far, 117 cases of infection across 34 states have been identified in the outbreak. The cases are in people ranging from infants to the elderly, including a 100-year-old. Of the cases, 61 (52 percent) have been hospitalized, and two deaths have been reported in Minnesota.

The CDC attributes the unusually high hospitalization rate to the fact that the pre-cut fruit was served at long-term care facilities and childcare centers. The elderly and young children are at higher risk of severe Salmonella illness.

Read 4 remaining paragraphs | Comments

Montana’s TikTok ban blocked by federal judge

Enlarge (credit: Bloomberg / Contributor | Bloomberg)

A federal judge has stopped a US state’s landmark ban on TikTok from going into effect, in an important test case for the widespread political backlash that has grown in the country against the Chinese-owned video-sharing app.

Montana’s Senate Bill 419, which was signed by the state’s Republican governor, Greg Gianforte, in May, would have gone into effect in January and imposed a ban on downloads of the app.

On Thursday, Judge Donald Molloy granted TikTok’s request for a preliminary injunction after the ByteDance-owned app challenged the legislation in court, denouncing it as an unconstitutional infringement of its rights. Some users of the app also joined the legal challenge.

Read 13 remaining paragraphs | Comments

Rocket Report: A mysterious explosion in China; Firefly tests new engine

Enlarge / Imagery from Europe's Sentinel-2 satellite shows the aftermath of an explosion on a test stand at the Jiuquan Satellite Launch Center in China. (credit: Sentinel Hub EO Browser/CC BY 4.0)

Welcome to Edition 6.21 of the Rocket Report!

Someone is always watching, and it's more difficult than ever to hide bad news. This is one of my mantras as a reporter who will always come down on the side of transparency. We've seen space companies and government agencies in the United States try to downplay setbacks, which, let's face it, are inevitable in the space business. In China, it looks like a recent test-firing of a rocket motor didn't go well. Unsurprisingly, Chinese officials haven't said a thing.

As always, we welcome reader submissions, and if you don't want to miss an issue, please subscribe using the box below (the form will not appear on AMP-enabled versions of the site). Each report will include information on small-, medium-, and heavy-lift rockets, as well as a quick look ahead at the next three launches on the calendar.

Read 23 remaining paragraphs | Comments