Functional skin—complete with hair and oil glands—grown in lab

Transplantation of the bioengineered, 3D tissue using mouse iPS cells labeled with GFP. (credit: Takashi Tsuji, RIKEN)

For the first time, researchers have coaxed a primordial ball of cells into a multi-layered, transplantable patch of skin, sporting hair follicles and functioning glands.

The mouse-based study, published in Science Advances, brings scientists closer to pulling off the feat in humans, which would provide synthetic skin grafts that could treat burn victims and patients with various skin diseases. “We are coming ever closer to the dream of being able to recreate actual organs in the lab for transplantation and also believe that tissue grown through this method could be used as an alternative to animal testing of chemicals,” lead researcher Takashi Tsuji, of the RIKEN Center for Developmental Biology in Japan, said in a statement.

Researchers have been getting better and better and recreating tissues in lab—but for skin, they had gotten stuck at making simplified versions. Fully functioning skin includes three layers: the epidermis, an outermost protective layer that is mostly waterproof; the elastic dermis layer that gives skin flexibility as well as housing oil and sweat glands, hair follicles, nerve endings, and blood vessels; and the subcutaneous fatty layer that provides padding and insulation.

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